Preventing cancer? Team IDs two pathways through which chromosomes are rearranged

Preventing cancer? Team IDs two pathways through which chromosomes are rearranged

A research team has identified two pathways through which chromosomes are rearranged in mammalian cells. Preventing these rearrangements could conceivably prevent cancer in some people.

via ScienceDaily: Top Health News:

Sep. 8, 2013 — Biologists reported today in Nature that they have identified two pathways through which chromosomes are rearranged in mammalian cells. These types of changes are associated with some cancers and inherited disorders in people.”Our finding provides a target to prevent these rearrangements, so we could conceivably prevent cancer in some high-risk people,” said senior author Edward P. (Paul) Hasty, D.V.M., of the School of Medicine at The University of Texas Health Science Center at San Antonio. Partial funding came from the Cancer Therapy & Research Center at the UT Health Science Center San Antonio.The two pathways rearrange chromosomes by recombining DNA repeats that are naturally found in the genome, Dr. Hasty said. DNA, the chemical substance of genes, denatures and replicates during cell division and other processes. Repeats are sequences of DNA that are duplicated.Both pathways are important for the synthesis of DNA. “Therefore, we propose that chromosomal rearrangements occur as DNA is being synthesized,” Dr. Hasty said.The experiments were conducted with mouse embryonic stem cells grown in tissue culture. …

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ScienceDaily: Top Health News

Preventing cancer? Team IDs two pathways through which chromosomes are rearranged

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