Body odor changes following vaccination
New research reveals that immunization can trigger a distinct change in body odor. This is the first demonstration of a bodily odor change due to immune activation. “This work provides further evidence that it is possible to use odors to ‘eavesdrop’ on the immune system, suggesting that non-invasive disease detection may be possible even before the onset of observable symptoms,” one of the researchers said.
Our understanding of the role of body odor in conveying personal information continues to grow. New research from the Monell Chemical Senses Center and the U.S. Department of Agriculture (USDA) reveals that immunization can trigger a distinct change in body odor. This is the first demonstration of a bodily odor change due to immune activation.The findings will appear in the April 10 issue of Physiology and Behavior. In addition, portions of the work will be presented on April 10 at the 36th Annual Meeting of the Association for Chemoreception Sciences (AChemS)in Bonita Springs, FL.”This work provides further evidence that it is possible to use odors to ‘eavesdrop’ on the immune system, suggesting that non-invasive disease detection may be possible even before the onset of observable symptoms,” says Bruce Kimball, PhD, a research chemist with the USDA National Wildlife Research Center (NWRC) stationed at the Monell Center. “The results have potential implications regarding disease surveillance in wildlife populations and food safety, bioterrorism, and human disease diagnosis.”In the study, ‘biosensor’ mice were trained to discriminate between urine odors from mice vaccinated against either the rabies virus (RV) or the West Nile virus (WNV). All training and testing trials were conducted using a Y-maze with odors randomly assigned to each arm of the “Y.”The biosensor mice were also trained to differentiate between urine from mice treated with lipopolysaccharide (LPS), a bacterial toxin that activates the immune system, and untreated urine.After completing training sessions, researchers conducted several validation trials using urine from unfamiliar individuals to exclude the possibility that individual odors, rather than treatment odors, were being detected. Following validation trials, several rounds of testing sessions were conducted.The biosensor mice clearly discriminated RV, WNV, and LPS urine odors from non-treated urine. Furthermore, biosensors also were able to differentiate between the vaccines and LPS odors. However no discrimination was made between RV and WNV odors.Together, the findings suggest that the two vaccines alter urine odor in similar ways, while an LPS-triggered immune response produces a qualitatively different body odor.”This research indicates that there is a pathway between immune activation and changes in the body odor compounds, revealing yet another kind of information stored in body odors,” said Monell behavioral biologist Gary Beauchamp, PhD, also an author on the paper. …
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