Lupus erythematosus and sunlight induced DNA Crash

Lupus erythematosus and sunlight induced DNA Crash

Summer, sun and the sea – a dream vacation for most – can turn sour for those affected by lupus erythematosus. For them, absorption of the UV-light component in sunlight may cause florid inflammation and redness of the skin. Scientists have now discovered which signaling pathway of the innate immune system promotes autoimmune symptoms following sun-induced DNA damage.

via ScienceDaily: Top Health News:

Aug. 29, 2013 — Summer, sun and the sea — a dream vacation for most — can turn sour for those affected by lupus erythematosus. For them, absorption of the UV-light component in sunlight may cause florid inflammation and redness of the skin. Scientists of the University Hospital Bonn, Germany have now discovered which signaling pathway of the innate immune system promotes autoimmune symptoms following sun-induced DNA damage. The results are now published online in the academic journal Immunity.Lupus erythematosus (LE) is an autoimmune disorder in which the immune system erroneously attacks the body’s own tissues. Where most people merely suffer sunburn, LE prone patients may develop severe redness and inflammation in sun-exposed skin. Immunologists of the University Hospital Bonn together with the Dermatologists Profs. Thomas Tüting and Jörg Wenzel have now discovered an immune mechanism that triggers LE skin lesions. “We have shown how the UV component of sunlight may cause DNA damage in cells, and in consequence lead to an alarm response from the innate immune system,” reports Dr. Winfried Barchet, head of the Emmy Noether-research team “Immunorecognition of viral nucleic acids in the cytosol” at the Institute of Clinical Chemistry and Clinical Pharmacology at the university clinics of Bonn.How DNA damage produces a false alarmHigh-energy UV irradiation damages DNA in the nuclei of living cells that in consequence perish, and release the UV-altered DNA. …

For more info: Lupus erythematosus and sunlight induced DNA Crash

ScienceDaily: Top Health News

Lupus erythematosus and sunlight induced DNA Crash

Utilizzando il sito, accetti l'utilizzo dei cookie da parte nostra. maggiori informazioni

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close