T-cell targeted therapy tested in type 1 diabetes study

T-cell targeted therapy tested in type 1 diabetes study

Results from the START clinical study (Study of Thymoglobulin to Arrest Newly Diagnosed Type 1 Diabetes) are now available. The study did not meet its primary endpoint: at 12 months, insulin production, as measured by C-peptide responses, showed no difference in overall decline between the treatment and placebo groups.

via ScienceDaily: Top Health News:

Aug. 27, 2013 — Results from the START clinical study (Study of Thymoglobulin to Arrest Newly Diagnosed Type 1 Diabetes), led by Dr. Steve Gitelman (University of California, San Francisco) and sponsored by the Immune Tolerance Network (ITN), are published today in The Lancet Diabetes & Endocrinology. The study did not meet its primary endpoint: at 12 months, insulin production, as measured by C-peptide responses, showed no difference in overall decline between the treatment and placebo groups.Thymoglobulin®, currently licensed for the treatment of organ transplant rejection, is a form of antithymocyte globulin (ATG), a mixture of specialized proteins called antibodies. These antibodies attach themselves to white blood cells known as T cells, interfering with their function and eliminating them temporarily from the bloodstream. During the development of type 1 diabetes, T cells mistakenly destroy the beta cells of the pancreas, which secrete insulin. ITN investigators hypothesized that treating new-onset type 1 diabetes with thymoglobulin would disrupt T-cell activation and might induce tolerance.The Phase II START study enrolled 58 new-onset type 1 diabetic patients ages 12 to 35 years old. The patients were randomized 2:1 to receive ATG treatment or placebo. Patients in the ATG group received intravenous infusion of ATG over 4 consecutive days at the start of the study; patients in the placebo group received saline solution. At 6-month intervals, researchers measured insulin production of patients in both groups. …

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ScienceDaily: Top Health News

T-cell targeted therapy tested in type 1 diabetes study

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