The number of tumor cells spread to sentinel lymph nodes affects melanoma prognosis

The number of tumor cells spread to sentinel lymph nodes affects melanoma prognosis

Cancer cell spread to the sentinel node — the lymph node to which cancer cells are most likely to spread from a primary tumor — is a risk factor for melanoma death. The prognosis of a patient largely depends on the number of disseminated cancer cells per million lymphocytes in the sentinel node. Even very low numbers were found to be predictive for reduced survival.

via Top Health News — ScienceDaily:

Cancer cell spread to the sentinel node — the lymph node to which cancer cells are most likely to spread from a primary tumor — is a risk factor for melanoma death. According to a study published in this week’s PLOS Medicine by Anja Ulmer, Christoph Klein and colleagues from the Universities of Tbingen and Regensburg, Germany, the prognosis of a patient largely depends on the number of disseminated cancer cells per million lymphocytes in the sentinel node. Even very low numbers were found to be predictive for reduced survival.The leading cause of death from skin disease is melanoma, which is the most dangerous type of skin cancer. When melanoma metastasizes and spreads to other parts of the body, treatment options become limited and the prognosis is poor. Melanoma staging (and prognosis) is currently focused on the primary tumor itself, with characteristics like tumor thickness, mitotic rate, and ulceration (break in the skin caused by the tumor) indicating the likelihood that the tumor has started to spread. Looking for tumor cells in the sentinel nodes is done for patients who are at increased risk for spread, but standard procedures for how to measure spread to the nodes and how to integrate this information with the tumor histology are needed. Since melanoma is one of the deadliest cancers, better predictors of prognosis for melanoma patients are needed for patient information and to determine treatment options.The researchers prospectively collected a large number of samples for this relatively rare cancer: 1,834 sentinel lymph nodes from 1,027 patients with melanoma who had been followed for 5 years after the samples were taken. They labelled disseminated cancer cells (DCCs) in the lymph nodes through the use of a marker for melanoma cells, counted them, and calculated DCC density. They then asked whether DCC density was related to a patient’s survival. They found that patients with high DCC density in the lymph nodes were more likely to die from melanoma within 5 years. …

For more info: The number of tumor cells spread to sentinel lymph nodes affects melanoma prognosis

Top Health News — ScienceDaily

The number of tumor cells spread to sentinel lymph nodes affects melanoma prognosis

Utilizzando il sito, accetti l'utilizzo dei cookie da parte nostra. maggiori informazioni

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close