Chlamydia protein has an odd structure, scientists find
Discovery of the structure of a protein secreted by the chlamydia bug may lead to novel therapies for the common sexually transmitted disease, which infects more than a million Americans annually.
June 11, 2013 — A protein secreted by the chlamydia bug has a very unusual structure, according to scientists in the School of Medicine at The University of Texas Health Science Center San Antonio. The discovery of the protein’s shape could lead to novel strategies for diagnosing and treating chlamydia, a sexually transmitted disease that infects an estimated 2.8 million people in the U.S. each year.The protein, Pgp3, is secreted by Chlamydia trachomatis, the bacterium that causes chlamydia. Pgp3’s shape is very distinguishable — sort of like an Eiffel Tower of proteins. “From a structural standpoint, the protein is very odd indeed,” said X-ray crystallographer P. John Hart, Ph.D., the Ewing Halsell President’s Council Distinguished Chair in the Department of Biochemistry at the San Antonio medical school. “This long and slender molecule contains a fusion of structural motifs that resemble those typically found in viral and not bacterial proteins.” Dr. Hart is co-lead author of the research, which is described in the Journal of Biological Chemistry (JBC).The Pgp3 protein is a chlamydial virulence factor that is hypothesized to enhance the bug’s ability to initially infect its human host and then evade host defenses. “Although my lab has worked on this protein for many years and gained a great deal of knowledge on it, we still don’t know what roles it may play in chlamydial pathogenesis (disease development),” said co-lead author Guangming Zhong, M.D., Ph.D., professor of microbiology at the Health Science Center. “With the structural information uncovered in this paper, we can now test many hypotheses.”This is the second chlamydial virulence factor that Dr. …
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